Cone Phosphodiesterase-6γ’ Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits
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چکیده
منابع مشابه
A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish.
Photoreceptor degeneration is a common cause of inherited blindness worldwide. We have identified a blind zebrafish mutant with rapid degeneration of cone photoreceptors caused by a mutation in the cone phosphodiesterase c (pde6c) gene, a key regulatory component in cone phototransduction. Some rods also degenerate, primarily in areas with a low density of rods. Rod photoreceptors in areas of t...
متن کاملCone phosphodiesterase-6α' restores rod function and confers distinct physiological properties in the rod phosphodiesterase-6β-deficient rd10 mouse.
Phosphodiesterase-6 (PDE6) is the key effector enzyme of the vertebrate phototransduction pathway in rods and cones. Rod PDE6 catalytic core is composed of two distinct subunits, PDE6α and PDE6β, whereas two identical PDE6α' subunits form the cone PDE6 catalytic core. It is not known whether this difference in PDE6 catalytic subunit identity contributes to the functional differences between rod...
متن کاملComplementary interactions of the rod PDE6 inhibitory subunit with the catalytic subunits and transducin.
Activation of the cyclic GMP phosphodiesterase (PDE6) by transducin is the central event of visual signal transduction. How the PDE6 inhibitory gamma-subunit (Pgamma) interacts with the catalytic subunits (Palphabeta) and the transducin alpha-subunit (alpha(t)) in this process is not entirely clear. Here we have investigated this issue, taking advantage of site-specific label transfer from thro...
متن کاملFunctional Mapping of Interacting Regions of the Photoreceptor Phosphodiesterase (PDE6) -Subunit with PDE6 Catalytic Dimer, Transducin, and Regulator
Background: The PDE6 -subunit serves multiple functions during visual transduction. Results: Several regions of P that interact with PDE6 or transducin were identified. Conclusion:Multiple interacting sites of P with PDE catalytic dimer, transducin, and the transducin/RGS9 complex coordinate the activation and deactivation of PDE6. Significance: This work contributes to understanding how defect...
متن کاملCorrection: A Hybrid Photoreceptor Expressing Both Rod and Cone Genes in a Mouse Model of Enhanced S-Cone Syndrome
Resequencing has shown that three clones used for making in situ hybridization (ISH) probes for this manuscript were initially misidentified (gene IDs from Figure 1: G17, G23, and G25). The correct identities of these clones are as follow: Glo1, Hnrpa1, and Dkk3, respectively. This finding led the authors to resynthesize and test all ten probes made in the batch which included these misidentifi...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2018
ISSN: 1662-5099
DOI: 10.3389/fnmol.2018.00233